| Объем | 100 мкл |
| Синонимы | Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, kinase ATM |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13315 |
| Иммуноген | Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 |
| Примечание | <p>ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. <br /><br />Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305. <br />Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252. <br />Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119. <br />Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724. <br /> ,</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser1981 |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Hela cells untreated or treated with UV using ATM(Phospho-Ser1981) Antibody
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM(Phospho-Ser1981) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: Phospho-ATM (Ser1981) Antibody.