| Объем | 100 мкл |
| Синонимы | CD115, CSF-1-R, CSFMR, FMS, M-CSFR |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P07333 |
| Иммуноген | Peptide sequence around phosphorylation site of tyrosine 561 (N-S-Y(p)-T-F) derived from Human CSFR . |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 |
| Примечание | <p>Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. <br/><br/>Hampe A., Oncogene Res. 4:9-17(1989).<br />Andre C., Genomics 39:216-226(1997).<br />Liu T., J. Proteome Res. 4:2070-2080(2005).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Tyr561 |
| Области исследований | Cardiovascular,Immunology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HepG2 cells treated with PMA using CSFR (Phospho-Tyr561) Antibody.The lane on the right is treated with the antigen-specific peptide.
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Immunohistochemical analysis of paraffin-embedded human brain, using CSFR (Phospho-Tyr561) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-CSF1R (Tyr561) Antibody.