Phospho-CTNNB1 (Tyr670) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Beta-catenin, catenin (cadherin-associated protein), beta 1, 88kDa, Catenin beta-1, CTNB1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P35222 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 670 (Q-W-Y(p)-K-K) derived from Human CTNNB1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr670 | | Области исследований | Neuroscience,Cancer,Cardiovascular,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from A549 cells, using Catenin-? (Phospho-Tyr670) antibody. The lane on the right is treated with the synthesized peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA064130 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-CTNNB1 (Tyr670) Antibody.
Примечание: дополнительная информация (на английском языке). |
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