| Объем | 100 мкл |
| Синонимы | PMYT1, PKMYT1, MYT1 kinase, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q99640 |
| Иммуноген | Peptide sequence around phosphorylation site of Serine 83(R-V-S(p)-F-R) derived from Human MYT1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | <p>The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<br/><br/>Booher R.N., J. Biol. Chem. 272:22300-22306(1997).<br />Liu F., Mol. Cell. Biol. 17:571-583(1997).<br />Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser83 |
| Области исследований | Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MYT1 (Phospho-Ser83) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-PKMYT1 (Ser83) Antibody.