Phospho-FOXO4 (Ser197) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AFX, FOXO4, AFX1, Afxh, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P98177 | | Иммуноген | Peptide sequence around phosphorylation site of serine 197 (A-A-S(p)-M-D) derived from Human AFX. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 | | Примечание | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. <br/><br/>Di Maira G, et al. (2005)Cell Death Differ, 12(6): 668-77.<br/>Essers MA, et al. EMBO J 2004 Nov. 11.<br/>Brownawell AM, (2001) Mol Cell Biol, 21(10): 3534-46.<br/>Kops GJ, et al. (1999) Nature, 398(6728): 630-4. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser197 | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells untreated or treated with serum using AFX(Phospho-Ser197) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AFX(Phospho-Ser197) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | Immunofluorescence staining of methanol-fixed MCF7 cells using AFX(Phospho-Ser197) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA591269 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-FOXO4 (Ser197) Antibody.
Примечание: дополнительная информация (на английском языке). |
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