Phospho-SMAD3 (Ser425) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | JV15-2, MAD-3, MADH3, Mad3, Mothers against DPP homolog 3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P84022 | | Иммуноген | Peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S(p)) derived from Human Smad3. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 | | Примечание | Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. <br/><br/>Shi W, et al. J Cell Sci. 2007 Apr 1,120(Pt 7):1216-24<br/>Seong HA, et al. J Biol Chem. 2007 Apr 20,282(16):12272-89<br/>Wordinger RJ, et al. Invest Ophthalmol Vis Sci. 2007 Mar,48(3):1191-200<br/>LeClair RJ, et al. Circ Res. 2007 Mar 30,100(6):826-33<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser425 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Metabolism,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells untreated or treated with EGF using Smad3(Phospho-Ser425) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Smad3(Phospho-Ser425) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA898915 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-SMAD3 (Ser425) Antibody.
Примечание: дополнительная информация (на английском языке). |
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