| Объем | 100 мкл |
| Синонимы | HD4 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P56524 |
| Иммуноген | Peptide sequence around phosphorylation site of serine 632 (A-Q-S(p)-S-P) derived from Human HDAC4. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | <p>Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. <br /><br />Wang AH, et al. (2000) Mol Cell Biol. 20(18): 6904-6912. <br />Grozinger CM, et al. (2000) Proc Natl Acad Sci U S A. 97(14): 7835-7840. <br /> ,</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser632 |
| Области исследований | Epigenetics and Nuclear Signaling,Cardiovascular,Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 cells untreated(lane 1) or treated with EGF(lane 2) using HDAC4(Phospho-Ser632) Antibody.
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Наименование: Phospho-HDAC4 (Ser632) Antibody.