Phospho-IGF1R (Tyr1280) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | IGFR, CD221, IGFIR | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P08069 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. <br /><br />Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093 <br />Baserga, R. et al. (2000) Oncogene 19, 5574-5581 <br />Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928. <br />O'Connor R, et al. Mol Cell Biol 1997 Jan, 17(1): 427-35</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Абревеатура | Phospho-Tyr1280 | | Области исследований | Cancer,Developmental biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from 293 cells using IGF-1R(Phospho-Tyr1280) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA449888 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-IGF1R (Tyr1280) Antibody.
Примечание: дополнительная информация (на английском языке). |
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