| Объем | 100 мкл |
| Синонимы | 1433Z, 143Z, FAS, Factor activating exoenzyme S, KCIP-1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P63104 |
| Иммуноген | Peptide sequence around phosphorylation site of serine 58 (R-S-S(p)-W-R) derived from Human 14-3-3 zeta. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 |
| Примечание | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.<br/><br/>Gu YM, et al. (2006) FEBS Lett , 580(1): 305-310<br/>Powell DW, et al. (2003) Mol Cell Biol, 23(15): 5376-5387<br/>Mackintosh C. (2004) Biochem J, 381(Pt 2): 329-342.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser58 |
| Области исследований | Neuroscience,Cell biology,Tags & Cell Markers,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Hela cells untreated or treated with UV using 14-3-3z(Phospho-Ser58) Antibody.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3z(Phospho-Ser58) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Immunofluorescence staining of methanol-fixed Hela cells using 14-3-3z(Phospho-Ser58) Antibody.
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Наименование: Phospho-YWHAZ (Ser58) Antibody.