| Объем | 100 мкл |
| Синонимы | MAPT, MTAPT, MTBT1, Neurofibrillary tangle protein, PHF-tau |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P10636 |
| Иммуноген | Peptide sequence around phosphorylation site of serine 404 (D-T-S(p)-P-R) derived from Human Tau. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 |
| Примечание | <p>Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. <br /><br />Li G, Yin H, et.al .(2004) J Biol Chem , 279(16): 15938-45. <br />Noble W, et al. (2003) Neuron , 38(4): 555-65. <br />Giasson BI, et al.(2002). Biochemistry, 41(51): 15376-87. <br />Lee G., et.al. (1989). Neuron 2:1615-1624. <br />Andreadis A.et.al. (1992) Biochemistry 31:10626-10633.</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Ser404 |
| Области исследований | Neuroscience,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from C6 cells, treated with calf intestinal phosphatase (CIP), using Tau (Phospho-Ser404) Antibody.
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Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer
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Immunofluorescence staining of methanol-fixed Hela cells using Tau(Phospho-Ser404) Antibody.
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Western blot analysis of extracts from C6 cells using Tau(Phospho-Ser404) Antibody.
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Наименование: Phospho-MAPT (Ser404) Antibody.