Phospho-MUSK (Tyr755) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | MUSK, Muscle, skeletal, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O15146 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. <br/><br/>Valenzuela D.M., Neuron 15:573-584(1995).<br />Humphray S.J., Nature 429:369-374(2004).<br />Bergamin E., Mol. Cell 39:100-109(2010).<br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr755 | | Области исследований | Tags & Cell Markers,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from JK cells (Lane 2), using MuSK (Phospho-Tyr755) Antibody. The lane on the left is treated with antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA204567 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-MUSK (Tyr755) Antibody.
Примечание: дополнительная информация (на английском языке). |
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