Phospho-SNCA (Ser129) Antibody

Спецификация

Объем	100 мкл
Синонимы	NACP, SYN, SYUA
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P37840
Иммуноген	Peptide sequence around phosphorylation site of serine 129 (M-P-S(p)-E-E) derived from Human a-Synuclein.
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB,WB:1:500-1:1000
Примечание	May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.<br/><br/>Takahashi T, et al. J Biol Chem 2003 Oct 24, 278(43): 42225-33<br/>Ahn BH, et al. J Biol Chem 2002 Apr 05, 277(14): 12334-42<br/>Negro A, et al. FASEB J 2002 Feb, 16(2): 210-2<br/>Goldberg, et al. Nat. Cell Biol. 2000, 2, 115-119.<br/>
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Абревеатура	Phospho-Ser129
Области исследований	Neuroscience
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts from mouse brain tissue using a-Synuclein(Phospho-Ser129) Antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	100 мкл
	Кат. номер:	CSB-PA585265
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Phospho-SNCA (Ser129) Antibody. Примечание: дополнительная информация (на английском языке).