PITX3 Antibody, FITC conjugatedСпецификация| Объем | 50 мкг | | Синонимы | Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3), PITX3, PTX3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O75364 | | Иммуноген | Recombinant Human Pituitary homeobox 3 protein (10-200AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | FITC | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Pituitary homeobox 3 | | Области исследований | Epigenetics and Nuclear Signaling, Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA010844LC01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: PITX3 Antibody, FITC conjugated.
Примечание: дополнительная информация (на английском языке). |
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