PRKACB AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.11.11, KAPB, KAPCB, PKA C-beta, PKA-beta | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P22694 | | Иммуноген | Synthesized peptide derived from internal of human KAPCB. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.<br/><br/>Beebe S.J., Mol. Endocrinol. 4:465-475(1990).<br/>Gregory S.G., Nature 441:315-321(2006).<br/>Wu K.-J., Oncogene 21:7872-7882(2002).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells and COLO205 cells, using KAPCB antibody.
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Наименование: PRKACB Antibody.