Объем | 50 мкг |
Синонимы | E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (95 kDa retinoblastoma-associated protein) (RBP95) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B), RNF40, BRE1B KIAA0661 |
Клональность | Polyclonal Antibody |
Организм | Human |
uniprot | O75150 |
Иммуноген | Recombinant Human E3 ubiquitin-protein ligase BRE1B protein (471-724AA) |
Источник | Rabbit |
Видовая специфичность | Human |
Применение | ELISA |
Примечание | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B, reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. |
Клональность1 | Polyclonal |
Изотип | IgG |
Коньюгат | HRP |
Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Форма | Liquid |
Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Метод очистки | >95%, Protein G purified |
Абревеатура | E3 ubiquitin-protein ligase BRE1B |
Области исследований | Cell biology |
Ссылка на страницу на сайте производителя | ссылка |
| |