PTAFR AntibodyСпецификация| Объем | 50 мкл | | Синонимы | Platelet-activating factor receptor | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P25105 | | Иммуноген | Synthetic peptide of human PTAFR | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, IHC,ELISA:1:1000-1:5000, IHC:1:25-1:100 | | Примечание | This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Cardiovascular,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA109839(PTAFR Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: ?200)
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Наименование: PTAFR Antibody.