PPIF AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Peptidyl-prolyl cis-trans isomerase, mitochondrial [Precursor], EC 5.2.1.8, PPIase, Rotamase | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P30405 | | Иммуноген | Synthesized peptide derived from internal of human PPIF. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis, the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F1F0 ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<br/><br/>Bergsma D.J., J. Biol. Chem. 266:23204-23214(1991).<br/>Deloukas P., Nature 429:375-381(2004).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cancer,Cell biology,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, 293 cells and HepG2 cells, using PPIF antibody.
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue using PPIF antibody.
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Наименование: PPIF Antibody.