PTPRJ AntibodyСпецификация| Объем | 50 мкл | | Синонимы | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148), PTPRJ, DEP1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q12913 | | Иммуноген | Recombinant Human Receptor-type tyrosine-protein phosphatase eta protein (140-370AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, IHC, Recommended dilution: IHC:1:20-1:200 | | Примечание | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration, through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation, through KDR dephosphorylation. Negative regulator of EGFR signaling pathway, through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen Affinity Purified | | Абревеатура | Receptor-type tyrosine-protein phosphatase eta | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA613274ESR1HU at dilution of 1:100
 | Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA613274ESR1HU at dilution of 1:100
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Наименование: PTPRJ Antibody.