RAD50 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | DNA repair protein RAD50, EC 3.6.-.-, hRAD50, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q92878 | | Иммуноген | Synthesized peptide derived from internal of human RAD50. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.<br/><br/>Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).<br/>Kim K.K., Gene 235:59-67(1999).<br/>Carney J.P., Cell 93:477-486(1998). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO205 cells, 293 cells and HUVEC cells, using RAD50 antibody.
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Наименование: RAD50 Antibody.