PSMD10 Antibody, Biotin conjugatedСпецификация| Объем | 50 мкг | | Синонимы | 26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK)), PSMD10 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O75832 | | Иммуноген | Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 protein (1-226AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | 26S proteasome non-ATPase regulatory subunit 10 | | Области исследований | Cancer, Cell biology | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA018899LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: PSMD10 Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
|
