PTPN22 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, lymphoid-specific protein tyrosine phosphatase, LyP, LYP1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9Y2R2 | | Иммуноген | Synthesized peptide derived from Internal of human PTPN22. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<br/><br/>Cohen S., Blood 93:2013-2024(1999).<br/>Liu T., Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.<br/>Wang S., Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.<br/> <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa/Jurkat cells, using PTPN22 antibody.
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Наименование: PTPN22 Antibody.