PTTG1 Antibody, HRP conjugatedСпецификацияОбъем | 100 мкг | Синонимы | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG), PTTG1, EAP1 PTTG TUTR1 | Клональность | Polyclonal Antibody | Организм | Human | uniprot | O95997 | Иммуноген | Recombinant Human Securin protein (2-202AA) | Источник | Rabbit | Видовая специфичность | Human | Применение | ELISA | Примечание | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | HRP | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | Форма | Liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | >95%, Protein G purified | Абревеатура | Securin | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Cell biology | Ссылка на страницу на сайте производителя | ссылка | | |
Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | Антитела | Объем: | 100 мкг | Кат. номер: | CSB-PA019074LB01HU | Цена (с НДС 20%): | по запросу | В корзину | Наименование: PTTG1 Antibody, HRP conjugated. Примечание: дополнительная информация (на английском языке). |
|