| Объем | 100 мкг |
| Синонимы | Repulsive guidance molecule A (RGM domain family member A), RGMA, RGM |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q96B86 |
| Иммуноген | Recombinant Human Repulsive guidance molecule A protein (153-408AA) |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
| Примечание | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Области исследований | Neuroscience, Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western Blot
All lanes: GCDH antibody at 12µg/ml
Lane 1: Mouse brain tissue
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50, 48, 51 kDa
Observed band size: 50 kDa
 |
Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA836186LA01HU at dilution of 1:100
 |
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA836186LA01HU at dilution of 1:100
 |
| | |
Наименование: RGMA Antibody.