SIRT7 Antibody, FITC conjugatedСпецификация| Объем | 50 мкг | | Синонимы | NAD-dependent protein deacetylase sirtuin-7 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7), SIRT7, SIR2L7 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9NRC8 | | Иммуноген | Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | FITC | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | NAD-dependent protein deacetylase sirtuin-7 | | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Metabolism | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA885703LC01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: SIRT7 Antibody, FITC conjugated.
Примечание: дополнительная информация (на английском языке). |
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