| Объем | 100 мкл |
| Синонимы | NRSF, XBR, REST |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13127 |
| Иммуноген | Peptide sequence around aa.873~877(R-E-E-A-S) derived from Human REST. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.<br/><br/>Chong J.A.et.al. (1995)Cell 80:949-957<br/>Schoenherr C.J.et.al.(1995)Science 267:1360-1363<br/>Scholl T.et.al.(1996)J. Immunol. 156:1448-1457<br/>Lunyak V.V.et.al. (2002)Science 298:1747-1752<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Epigenetics and Nuclear Signaling,Neuroscience |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extract from Hela cells using REST Antibody
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Наименование: REST Antibody.