| Объем | 100 мкл |
| Синонимы | Serine/threonine-protein kinase 36 EC 2.7.11.1, Fused homolog STK36, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9NRP7 |
| Иммуноген | Synthesized peptide derived from internal of human STK36. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.<br/><br/>Murone M., Nat. Cell Biol. 2:310-312(2000).<br/>Nagase T., DNA Res. 6:337-345(1999).<br/>Hillier L.W., Nature 434:724-731(2005).<br/><br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Cancer,Cell biology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from K562 cells, using STK36 antibody.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using STK36 antibody.
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Наименование: STK36 Antibody.