RUNX1 AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit), RUNX1, AML1 CBFA2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q01196 | | Иммуноген | Recombinant Human Runt-related transcription factor 1 protein (211-445AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IF, Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 | | Примечание | CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the Mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Runt-related transcription factor 1 | | Области исследований | Epigenetics and Nuclear Signaling, Neuroscience, Cancer, Developmental biology, Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescent analysis of HepG2 cells using CSB-PA862035LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
 | Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: RUNX1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49, 51, 28, 29, 25, 21, 27, 52, 50, 38 kDa
Observed band size: 49, 51 kDa
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Наименование: RUNX1 Antibody.