| Объем | 100 мкл |
| Синонимы | JV18-1, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q15796 |
| Иммуноген | Synthesized non-phosphopeptide derived from human Smad2 around the phosphorylation site of threonine 220 (P-E-T(p)-P-P). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<br/><br/>Riggins G.J., Nat. Genet. 13:347-349(1996).<br/>Zhang Y., Nature 383:168-172(1996).<br/>Eppert K., Cell 86:543-552(1996).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction,Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from RAW264.7 cells and 293 cells, using Smad2 (Ab-220) antibody.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue using Smad2 (Ab-220) antiobdy.
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Наименование: SMAD2 (Ab-220) Antibody.