Socs3 AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3), Socs3, Cish3 | | Клональность | Polyclonal Antibody | | Организм | Rat | | uniprot | O88583 | | Иммуноген | Recombinant Rat Suppressor of cytokine signaling 3 protein (1-225AA) | | Источник | Rabbit | | Видовая специфичность | Human, Rat | | Применение | ELISA, WB, Recommended dilution: WB:1:500-1:2000 | | Примечание | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Immunology, Metabolism, Signal transduction, Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot
All lanes: Socs3 antibody at 12µg/ml
Lane 1: K562 whole cell lysate
Lane 2: A375 whole cell lysate
Lane 3: Hela whole cell lysate
Lane 4: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25 kDa
Observed band size: 25 kDa
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Наименование: Socs3 Antibody.