SELENON AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Selenoprotein N (SelN), SELENON, SELN SEPN1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9NZV5 | | Иммуноген | Recombinant Human Selenoprotein N protein (135-219AA) | | Источник | Rabbit | | Видовая специфичность | Human, Rat | | Применение | ELISA, WB, Recommended dilution: WB:1:500-1:5000 | | Примечание | Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Selenoprotein N | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Western Blot
Positive WB detected in: Rat brain tissue, Rat lung tissue
All lanes: SELENON antibody at 4.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66, 63 kDa
Observed band size: 66 kDa
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Наименование: SELENON Antibody.