STAT2 (Ab-690) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | P113, ISGF-3, STAT113 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P52630 | | Иммуноген | Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus.<br/><br/>Fu, X. et al. (1992) Biochemistry 89, 7840-7843.<br/>Park, C. et al. (2000) Immunity 13, 795-804.<br/>Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964.<br/>Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells using STAT2(Ab-690) Antibody and the same antibody preincubated with blocking peptide.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2(Ab-690) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: STAT2 (Ab-690) Antibody.