Synpr AntibodyСпецификацияОбъем | 100 мкл | Синонимы | Synpr | Клональность | Polyclonal Antibody | Организм | Mouse | uniprot | P22831 | Иммуноген | Peptide sequence around aa.257~261(G-P-T-S-F)derived from Rat synaptophysin 2. | Источник | Rabbit | Видовая специфичность | Mouse, Rat | Применение | ELISA, WB,WB:1:500-1:1000 | Примечание | <p>Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that is expressed in neuroendocrine cells and neoplasms, and thus can be used as a marker in tumor diagnosis (1). Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore (2). Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases (3). Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex (4). <br /><br />Wiedenmann, B. et al. (1986) Proc Natl Acad Sci USA 83, 3500-4. <br />Valtorta, F. et al. (2004) Bioessays 26, 445-53. <br />Arthur, C.P. and Stowell, M.H. (2007) Structure 15, 707-14. <br />Bonanomi, D. et al. (2007) Biochem J 404, 525-34.</p> | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | Non-conjugated | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | Форма | liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | Области исследований | Neuroscience | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from rat brain and mouse brain using synaptophysin 2 Antibody.
| | |
Информация для заказа |