SMAD4 AntibodyСпецификация| Объем | 50 мкл | | Синонимы | MAD homolog 4,Mothers against DPP homolog 4,Deletion target in pancreatic carcinoma 4,SMAD family member 4,SMAD 4,Smad4,SMAD4,DPC4,MADH4 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13485 | | Иммуноген | Recombinant Human Mothers against decapentaplegic homolog 4 protein | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC | | Примечание | In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site, required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen Affinity purified | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Metabolism,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | | | |
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Наименование: SMAD4 Antibody.