| Объем | 100 мкг |
| Синонимы | Signal transducer and activator of transcription 3 (Acute-phase response factor), STAT3, APRF |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P40763 |
| Иммуноген | Recombinant Human Signal transducer and activator of transcription 3 protein (50-240AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC, IF, IP, Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500, IP:1:200-1:2000 |
| Примечание | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | Signal transducer and activator of transcription 3 |
| Области исследований | Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA022812LA01HU at dilution of 1:100
 |
Immunofluorescent analysis of HepG2 cells using CSB-PA022812LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
 |
Immunoprecipitating STAT3 in Hela whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA022812LA01HU in Hela whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA022812LA01HU (6µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)
 |
| | |
Наименование: STAT3 Antibody.