SPIN1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | OCR, Ovarian cancer-related protein, Spindlin-1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9Y657 | | Иммуноген | Synthesized peptide derived from internal of human SPIN1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.<br/><br/>Zhang H.L., Chin. Sci. Bull. 45:909-914(2000). <br/>Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005).<br/>Humphray S.J., Nature 429:369-374(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Developmental biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, using SPIN1 antibody.
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Наименование: SPIN1 Antibody.