| Объем | 50 мкг |
| Синонимы | TAR DNA-binding protein 43 (TDP-43), TARDBP, TDP43 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13148 |
| Иммуноген | Recombinant Human TAR DNA-binding protein 43 protein (1-396AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC, IF, Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Примечание | DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | TAR DNA-binding protein 43 |
| Области исследований | Epigenetics and Nuclear Signaling, Neuroscience, Microbiology |
| Ссылка на страницу на сайте производителя | ссылка |
Western Blot
Positive WB detected in: K562 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate, HL60 whole cell lyasate, MCF-7 whole cell lysate, HepG2 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: TARDBP antibody at 2.5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 32 kDa
Observed band size: 45 kDa
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023129EA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA023129EA01HU at dilution of 1:100
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Immunofluorescent analysis of HepG2 cells using CSB-PA023129EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Наименование: TARDBP Antibody.