TH (Ab-31) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | TYH, DYT14, DYT5b, TH, | | Клональность | Polyclonal Antibody | | Организм | Mouse | | uniprot | P07101 | | Иммуноген | Peptide sequence around aa.29~33(V-T-S-P-R)derived from Mouse Tyrosine Hydroxylase. | | Источник | Rabbit | | Видовая специфичность | Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer, with each subunit composed of a regulatory and catalytic domain, and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription, translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.<br/><br/>Kumer, S.C. and Vrana, K.E. (1996) J Neurochem 67, 443-62. <br/>Bodeau-P | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Neuroscience,Cancer,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from rat brain and mouse brain using Tyrosine Hydroxylase(Ab-31) Antibody.
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Наименование: TH (Ab-31) Antibody.