| Объем | 100 мкл |
| Синонимы | deubiquitinating enzyme 19, EC 3.1.2.15, KIAA0891, UB19, ubiquitin carboxyl-terminal hydrolase 19 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O94966 |
| Иммуноген | Synthesized peptide derived from internal of human USP19. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.<br/><br/>Nagase T., DNA Res. 5:355-364(1998).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 3T3 cells, using USP19 antibody.
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using USP19 antibody.
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Наименование: USP19 Antibody.