TSPAN12 Antibody, Biotin conjugatedСпецификацияОбъем | 50 мкг | Синонимы | Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12), TSPAN12, NET2 TM4SF12 | Клональность | Polyclonal Antibody | Организм | Human | uniprot | O95859 | Иммуноген | Recombinant Human Tetraspanin-12 protein (111-224AA) | Источник | Rabbit | Видовая специфичность | Human | Применение | ELISA | Примечание | Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | Biotin | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | Форма | Liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | >95%, Protein G purified | Абревеатура | Tetraspanin-12 | Области исследований | Neuroscience, Cell biology | Ссылка на страницу на сайте производителя | ссылка | | |
Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | Антитела | Объем: | 50 мкг | Кат. номер: | CSB-PA025149LD01HU | Цена (с НДС 20%): | по запросу | В корзину | Наименование: TSPAN12 Antibody, Biotin conjugated. Примечание: дополнительная информация (на английском языке). |
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