WNK4 Antibody, FITC conjugatedСпецификацияОбъем | 100 мкг | Синонимы | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4), WNK4, PRKWNK4 | Клональность | Polyclonal Antibody | Организм | Human | uniprot | Q96J92 | Иммуноген | Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA) | Источник | Rabbit | Видовая специфичность | Human | Применение | ELISA | Примечание | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | FITC | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | Форма | Liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | >95%, Protein G purified | Абревеатура | Serine/threonine-protein kinase WNK4 | Области исследований | Signal transduction | Ссылка на страницу на сайте производителя | ссылка | | |
Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | Антитела | Объем: | 100 мкг | Кат. номер: | CSB-PA842690LC01HU | Цена (с НДС 20%): | по запросу | В корзину | Наименование: WNK4 Antibody, FITC conjugated. Примечание: дополнительная информация (на английском языке). |
|