XRCC2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | X-RAY REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 2, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43543 | | Иммуноген | Synthesized peptide derived from internal of human XRCC2. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.<br/><br/>JP Scott, Blood, Oct 1981, 58: 665 - 669. <br/>G Chevalier, Am. J. Pathol., Jun 1998, 152: 1563. <br/>R Williams, J. Biol. Chem., Aug 1993, 268: 18213 - 18217. <br/>Michael R. Ladomery, J. Biol. Chem., Dec 1999, 274: 36520.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293cells, using XRCC2 antibody.
 | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using XRCC2 antibody.
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Наименование: XRCC2 Antibody.