CAV1 (Ab-14) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CAV, CAV1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q03135 | | Иммуноген | Peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (a and beta) are encoded by a single transcript from this gene.<br/><br/>Zhang Y, et al. (2005) Mol Cell Proteomics. 4(9): 1240-1250.<br/>Labrecque L, et al. (2004) J Biol Chem. 279(50): 52132-52140.<br/>Fielding PE, et al. (2004) Biochemistry. 43(9): 2578-2586.<br/>Labrecque L, et al. (2003) Mol Biol Cell. 14(1): 334-347.<br/>Maggi D, et al. (2002) Biochem Biophys Res Commun. 295(5): 1085-1089.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Cardiovascular,Tags & Cell Markers,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 and HUVEC cells using Caveolin-1(Ab-14) Antibody.
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Наименование: CAV1 (Ab-14) Antibody.