| Объем | 100 мкл |
| Синонимы | antigen p25, chromobox protein homolog 5, heterochromatin protein 1 alpha, HP1 alpha, HP1A |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P45973 |
| Иммуноген | Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F). |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<br/><br/>Saunders W.S., J. Cell Sci. 104:573-582(1993).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Ye Q., J. Biol. Chem. 271:14653-14656(1996).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Tags & Cell Markers |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1 alpha (Ab-92) antibody.
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Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1 alpha (Ab-92) antibody.
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Наименование: CBX5 (Ab-92) Antibody.