FOXO4 (Ab-197) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AFX, FOXO4, AFX1, Afxh, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P98177 | | Иммуноген | Peptide sequence around aa. 195~199 (A-A-S-M-D) derived from Human AFX. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. <br/><br/>Di Maira G, et al. (2005)Cell Death Differ, 12(6): 668-77.<br/>Essers MA, et al. EMBO J 2004 Nov. 11.<br/>Brownawell AM, (2001) Mol Cell Biol, 21(10): 3534-46.<br/>Kops GJ, et al. (1999) Nature, 398(6728): 630-4. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 and THP1 cells using AFX(Ab-197) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using AFX(Ab-197) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: FOXO4 (Ab-197) Antibody.