FZD4 Antibody, FITC conjugatedСпецификацияОбъем | 50 мкг | Синонимы | Frizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344), FZD4 | Клональность | Polyclonal Antibody | Организм | Human | uniprot | Q9ULV1 | Иммуноген | Recombinant Human Frizzled-4 protein (37-222AA) | Источник | Rabbit | Видовая специфичность | Human | Применение | ELISA | Примечание | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | Клональность1 | Polyclonal | Изотип | IgG | Коньюгат | FITC | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | Форма | Liquid | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | Метод очистки | >95%, Protein G purified | Абревеатура | Frizzled-4 | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Signal transduction, Stem cells | Ссылка на страницу на сайте производителя | ссылка | | |
Информация для заказаОбласть использования: | Производство: | Cusabio | Метод: | Антитела | Объем: | 50 мкг | Кат. номер: | CSB-PA890755LC01HU | Цена (с НДС 20%): | по запросу | В корзину | Наименование: FZD4 Antibody, FITC conjugated. Примечание: дополнительная информация (на английском языке). |
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