HDAC9 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | HDAC7B, HDAC9A, MITR, HISTONE DEACETYLASE 7B, KIAA0744 HISTONE DEACETYLASE 9A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9UKV0 | | Иммуноген | Synthesized peptide derived from human HDAC9. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription. Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.<br/><br/>Michael Haberland, Mol. Cell. Biol., Jan 2007, 27: 518 - 525.<br/>Xianbo Zhou, PNAS, Sep 2001, 98: 10572.<br/>Kevin Petrie, J. Biol. Chem., Apr 2003, 278: 16059 - 16072.<br/>Kevin Petrie, Blood (ASH Annual Meeting Abstracts), Nov 2004, 104: 1120.<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cardiovascular | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells, using HDAC9 antibody.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC9 antibody.
 | Immunofluorescence analysis of HepG2 cells, using HDAC9 antibody.
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Наименование: HDAC9 Antibody.