LCN2 Monoclonal AntibodyСпецификация| Объем | 50 мкг | | Code NO# | 3B1C10 | | Синонимы | NGAL,25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2 | | Тип антител | Monoclonal Antibody | | Видовая специфичность | Human | | Uniport ID | P80188 | | Иммуноген | Recombinant Human Neutrophil gelatinase-associated lipocalin protein | | Источник | Mouse | | Видовая специфичность 1 | Human,Mouse | | Перекрестная реактивность | CSB-MA068341A0m is specific for Lipocalin 2, native and denatured forms | | Применение | ELISA,WB,Recommended dilution:WB:1:500-1:5000 | | Примечание | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. | | Изотип | IgG2b | | Метод очистки | >95%,Protein G purified | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Области исследований | Cancer,Cardiovascular,Immunology,Metabolism,Signal transduction | | Станица на сайте производителя | ссылка | All lanes:Mouse anti-human Neutrophil gelatinase-associated lipocalin monoclonal antibody at 1ug/ml
Lane 1:NGAL transfected 293 cell lysate
Predicted band size : 22 kDa
Observed band size : 25 kDa
 | Immunohistochemical of paraffin-embedded human spleen organization using CSB-MA068341A0m at dilution of 1:200
 | Immunohistochemical of paraffin-embedded human prostate tissue using CSB-MA068341A0m at dilution of 1:200
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Наименование: LCN2 Monoclonal Antibody.