| Объем | 50 мкл |
| Синонимы | dihydrolipoamide S-acetyltransferase |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P10515 |
| Иммуноген | Fusion protein of human DLAT |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC,ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:30-1:150 |
| Примечание | This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen affinity purification |
| Области исследований | Cancer,Metabolism,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA084734(DLAT Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ?200)
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The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA084734(DLAT Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ?200)
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Gel: 8%SDS-PAGE, Lysate: 40 ?g, Lane 1-3: A431, hepg2 and lncap cell, Primary antibody: CSB-PA084734(DLAT Antibody) at dilution 1/800 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
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Наименование: DLAT Antibody.