E2F6 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | E2F-6, E2F transcription factor 6 isoform 1, E2F transcription factor 6 isoform 2, E2F transcription factor 6 isoform 3, E2F transcription factor 6 isoform 4 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O75461 | | Иммуноген | Synthesized peptide derived from human E2F6. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.<br/><br/>Matthew J. Oberley, J. Biol. Chem., Oct 2003, 278: 42466 - 42476.<br/>Claire Attwooll, J. Biol. Chem., Jan 2005, 280: 1199 - 1208.<br/>Paloma H. Giangrande, Genes & Dev., Dec 2004, 18: 2941 - 2951.<br/>J rg Storre, J. Biol. Chem., Dec 2005, 280: 41380 - 41386.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human brain tissue using E2F6 antibody.
 | Western blot analysis of extracts from HepG2 cells, using E2F6 antibody.
 | Western blot analysis of extracts from colo cells (Lane 2), using E2F6 antiobdy. The lane on the left is treated with synthesized peptide.
 | | | |
Информация для заказа |
Наименование: E2F6 Antibody.