| Объем | 50 мкг |
| Синонимы | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4), FBXW7, FBW7 FBX30 SEL10 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q969H0 |
| Иммуноген | Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, IHC, Recommended dilution: IHC:1:20-1:200 |
| Примечание | Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | F-box/WD repeat-containing protein 7 |
| Области исследований | Cancer, Cell biology |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemistry analysis of human kidney tissue using CSB-PA822163LA01HU at dilution of 1:100
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Immunocytochemistry analysis of human small intestine tissue using CSB-PA822163LA01HU at dilution of 1:100
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Наименование: FBXW7 Antibody.